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All can have their place in the grand scheme of the Machine God. Even psykers, as much as we may dislike the warp.
There are still sanctioned psykers, whose presence cannot (currently) be denied. The astropath, the navigator, these are essential and the benefit they provide to the efficiency of spaceflight is undeniable. Even if we do in secret work to make them nonessential.
Just as there are sanctioned Xenos, whose continued existence provides important samples and specimens for knowledge, even if all Xenos are less in the eyes of the machine god.
The Machine Gods faith and followers are a spectrum, upon which the dial may shift back and forth to whichever progresses his plans. Just as a pressure gauge must on occasion shift from highs to lows in the workings of a machine. From the most puritan of Martian priests who would not dare that a single molecule of Xenos material so much as touch his sacred temple, to the most secretive of Stygian Xenarites experimenting in the dark depths but with good cause in mind.
The Puritan risks the sin of wilfully shunning the quest for knowledge, or even of destruction of knowledge of the ancients because his fallible mortal mind cannot comprehend it. He shuns understanding, and thus comprehension, and in doing so shuns the Quest for knowledge. This risks damnation. As does, obviously, the Xenarite Stygian who treads in dark places. The Machine Gods hand is upon their shoulders, watching their actions and choices, hoping that they select the correct decision and do not tread from the true path.
Talos will have to toe this delicate balance himself one day. In fact he very much does so now. We know for a fact that much of this Blackstone Fortress, does hold Xenos technology and touch. We know that it held a Xenos warp spirit, which we crushed. But we did not opt to destroy the structure with it, but harness it to the Machine Gods purpose.