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Regarding broader urgencies, the map shows you where you are relative to all other landmarks in the Valley of Barovia.
For your main quest (ensuring the safety of Ireena) you don't currently have anything you might generously call a lead - all you know is that Ireena and Vasili von Holtz said they were heading east when they departed Vallaki, and that they would be closer to Castle Ravenloft and the Village of Barovia. If Ireena is in any danger with the strange noble, some clever words sent to via a paper bird might trick them into giving information that would allow you confirm her status safely. Or you could track them physically, which would give you the benefit of secrecy.
Either way, there is an even more pressing concern at this moment: it is unsafe in all directions. The woods are full of danger. The nearest settlement is Vallaki, and the part you played in the chaos that erupted there last time means re-entering now may be your worst mistake. Same with Krezk, and its cursed Abbey, with that Abbot still alive at least... You need a new base of operations.
Looking over the map, vote on an immediate location to travel to, as well as the route to get there.
The party's position is marked with the sword. For reference, Vallaki is about 6 hours away. Travel times can be calculated for any destination based on route and hex size.
The route you select and the amount of time you spend in travel will affect the type and quantity of dangerous encounters you may face along the way. There are distinct encounter tables for different regions and times of day - it's more dangerous in the woods at night, for example, especially for a party of two.
Make your choice:
>Follow Ezmerelda to her destination - an abandoned wizard's tower by Lake Zarovich.
>Split off with Joannus. Get set on the trail now, eastward to Barovia. It's a long distance, but the village is the only safe settlement left.
>Explore your immediate surroundings. Follow the trail south, taking either the east branch or the west branch.
>Go west, then head downward, toward where the map claims the winery is. You may not be able to solve the wine issue, but maybe it's safe there.
>Take your chances returning to Vallaki and find out what the city has become. It's close, but if you're stealthy, maybe you can hide out there, and maybe even make connections that could help with Ireena.
>Head out into uncharted lands. Go north, into the Svalich Woods - you will find salvation circling around the north of Lake Zarovich.
>Something else. (If you're inclined, feel free to download the map, mark a position, and draw a path of travel - just make sure there's a purpose.)