https://warhammer40k.fandom.com/wiki/Blank_(Psychic)>As large groups of Pariahs were brought to Terra, they began to cast a shadow in the Warp, blocking out the Astronomican, the vital psychic beacon used to guide starships to the far reaches of the Imperium. Other branches within the Imperium of Man, especially those that relied upon the abilities of psykers, were horrified by the existence of Pariahs.>Several members of the Council of Terra sought to have Pariahs outlawed outright like other dangerous mutants -- tasking the Sisters of Silence with the ruthless extermination of any more Blanks that were found just as they eliminated Renegade psykers who presented a threat to Humanity. A number of members of the Council of Terra, including the Paternal Envoy of the Navis Nobilite, were pushing the Emperor of Mankind to issue an official decree to rid the Imperium of the "anti-psyker" mutants that threatened their Adeptas' very existence.>This was unfortunate, for the Officio Assassinorum had been working in secret with the Magos Biologis and Genetors of the Mechanicum on the order of Malcador the Sigillite, the Regent of Terra and the founder of the Officio as the first Grand Master of Assassins, to see if it was possible to harness the Blanks' strange abilities and use them to kill psykers. Their work was almost complete; many years had been spent developing specialist wargear and training techniques, all of which was about to be ruined by a zealous political witch-hunt.>Fortunately, the Emperor never had to issue an official decree, for at Malcador the Sigillite's behest, the Mechanicum announced that it was ending the Pariah Project, making a great show of closing down its laboratories and executing many of the "specimens" it had tested there.This is the big mistake we can avoid or continue here, and by the Machine God I hope nobody actually wants to repeat this as it went down in OTL.
I'm sure we'll pay for it in some other horrible way by shifting the blank collection process to Xana or turning it into a Pariah Zone field, but at least we would keep our promise to Vera and Trig about making a world where their kind are not proscribed but seen as useful.