>>6000363>is to stick to a popular setting. That's it.Wrong.
OC settings are instantly more intriguing and appealing, easier to run and create things for, have a stronger author voice, and you don't have to worry about contradicting something written in one wiki memorized by an autist in 2013. While you might get a few people interested in your Quest because of the original setting's popularity, you're just as likely to drive people away because now not only do yo have to keep interest like a regular quest BUT you also can't run something they intrinsically don't like. D&D is a really good example, because while there are several popular D&D Quests on here and it has heavy overlap with Questing in general, there are some people who DESPISE D&D's core settings with a passion and will never play in those Quests, despite otherwise being fantasy loving nerds. And yes, if you run the latest SLOP you'll get more players, but those players won't stick around long. Most Quests go on for multiple years if you don't flake- do you really think everyone is going to stick around when the FOTM anime fans lose interest in your "what if anime but isekai" quest? Not a chance.
The ACTUAL way to attract interest and an audience is the fundamentals. Good presentation, interesting hook, and consistent upload schedule. Anything else is cope.