>>10589610No. HO is 1:87, the 6-stud wide trains that come in sets are around S scale (1:64), and a lot of people make custom 8-stud wide trains that are right around O-scale (1:48 in the US, or 1:43 elsewhere).
As
>>10589933 said, the gauge is about 1:38, and off the top of my head, I think minifig scale is typically considered 1:42, so 8-stud wide trains are both minifig scale and O-scale.