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Toy lines that you felt were 100% completely mishandled.
I'll start.
For me, it was probably toys for the series Kim Possible. Show was all audiances but the toys were mostly aimed at girls and little kids. You either had barbie styled dolls or one or two gimmick toys like Kim with magnet feet. Oh and a couple plushies of rufus. If you wanted villains, who were big parts of the show, you pretty much had like 3 mcondalds toys. No dolls of the villians. No action figures of anyone. No playsets.
Disney has a history of this btw. Making shows that are all audiences, then making no toys or toys targeted to just girls.