>>5392364There's some guy who made a littleknown program called Brickwizard. You imput pieces as a shopping list and it scans Bricklink for the cheapest combos. You can even specify how many orders you would want to make max to complete the list (if possible).
Speaking from experience, as builder of pic related.
Also, Mixel joints are great, but as mentioned above, new techniques seldom just replace old ones. They just become new options.