>>11042120Depending on the type of layout you're trying to make, different track plans will be better.
If you're trying to make a prototypical-operations focused layout, it might be better to figure out what facilities or industries are present and making the most direct and simple way to where rolling stock needs to go. Railroads realistically always looked to spend the least amount of money on building track as possible.
If you're just building a layout for your trains to do laps on, I wouldn't really be able to give you an exact direction, it's ultimately up to you. Though two running tracks are usually pretty good.