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Can we all stop pretending we don't know how this is gonna end?
Serena will stay in Kalos while Ash goes on to the next region. They will have a moving goodbye scene and Serena will tell him she really liked travelling with him, with emphasis on "really liked", hoping he catches on. Ash will smile and say he did too, and leave.
Amourfags will claim their ship canon and call anyone who disagrees a delusional shitposter
Normalfags will claim the ship sunk and call amourfags delusional shitposters
Then the next pokegirl will appear and it will START ALL OVER AGAIN