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North/South Carolina.
>Decent natural layout for a region, enough freedom and guidelines to work with
>Plenty of habitats to work with, Mountains, Beaches, Sand Dunes, Swamps, Forests
>Fun Southern US aesthetic that could differentiate itself from Unova, going for a more rural feel with plantation homes and backwater towns
>Plenty of history and iconic landmarks that could be easily poke-fied (such as Wright Brothers monument, Blackbeard's house, South of the Border, and so on)
I don't think it will happen since these days Pokemon regions are pretty big locations instead of niche ones like Arizona, but I can dream