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As for Nuzlocke, other than it encouraging grinding, the "first pokemon in each area rule" doesn't make sense to the narrative. Why would that be a restriction in that world? I know that's a dumb and petty reason and the way it makes the narrative more interesting (by encouraging the use of less used Pokemon and reducing the number of Pokemon you can catch and therefore making you more attached to them) outweighs that small negative, I do wonder if there are better ways...