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Serena will be the rival of the series. She'll have an epiphany, part with the group and when we meet here again, she'll be caught up with Ash and they'll rival it out.
Then in the grand finale, Ash can't bare the idea of seeing Serena's hard work go to waste so he'll pretend to lose, give her the glory. Then as the episode ends in the finale, Ash departs for Kanto and Serena will hesitatingly ask Ash if she can go with him but only lets out a stutter to which Ash asks to repeat her question but she quickly denies it. Leaving a loose end on what Serena was supposed to say, Ash leaves for Kanto to his new adventure hoping to become a Pokemon Master elsewhere.
Serena then returns home to meet her Drew equivalent which is a fellow Ryhorn racer.