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I'm not against gender reassignment, but we should wait for the technology to edit chromosomes at the cellular level or something like that, instead of Icarus jumping off the cliff and calling it the dream of flying come true.
Being trans should be more about pushing cultural norms, not pretending that you can rewrite biology. Unless it is a serious mental delusion that should be treated with therapy.
Transgender Pokemon can be an interesting concept for a gimmick species. They are fantastic creatures anyway, and there may be some precedents in nature.