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Update on my nuzlocke.
I have to be ultra lucky or something since I cannot tell you how many times instead of getting killed Ariadne, Atropos and Isaac will instead go down to 1-3HP.
I play it ultra safe and always have as many super potions and paralyz/antitode/awakening/burn heals as possible.
Just have made some stupid mistakes leading to the loss of Andrea and Rose.