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>The Name
Edina Region.
>Based On what real place
Mediterranean Coastline
>Local Villain Team(s)
Giratina Worshippers.
>Gyms/trials/the league members, etc. (whatever you feel like)
Cities with gyms should be located at the sites of, and themed around historically important major cities. Barcelona, Cairo, Rome, Athens, Carthage, Constantinople etc...
The Pokémon League is in Sparta.
>The general theme
Ancient Mythology.
Different areas of the map used to worship various gods in their prehistory. With Pokémon stand-ins being given high standing in each area.
The Egypt-like area holds Lucario (Anubis) in high regard, while the Greek-like area loves Machamp (Atlas/Hercules).
>Ideas you might have for starters or other pokemon in the region
Starters are a fire-type dog that evolves into a cerberus.
A water-type squid that evolves into a kraken.
And a grass-type snake that evolves into a humanoid Medusa-style creature.