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I think this is the biggest gameplay change, I'll try and keep it brief
>when you beat a trainer normally, they'll become inactive until you "rest" at a pokemon center, kind of like dark souls
>if you perfect a trainer, beat them with none of your pokemon fainting, that trainer will fuck off forever and drop several exp candies
you can totally clear routes of trainers completely, and while I haven't received an in-game reward for doing that on it's own it feels satisfying