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I'm pretty sure we all know Serena helps give Ash some sort of boost when times need be (at least if the opponent isn't above him to the point it doesn't matter like with Alain), as long as we still have her around by the league we may be able to win the gold and go home.
Serena is our weapon anons, the weapon to finally win this fight and then the war. Without her, all is lost.
