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>Kanto is reduced to a small path along Mt. Moon where you fight Brock, Misty and Red
>No following pokemon
>Pokelathon dome is now a focal point of the game, there is a 15 minute cutscene of Whitney taking you there and making you sign up for you to be forced into doing at least one match
>Pikachu is now on every route directly outside of a city
>No togepi egg, only Eevee; togepi egg is a gift from Misty after beating Red, much like Beldum
>Pokewalker comes separately for $50, is the only way to get certain pokemon since only their baby forms will appear and only in the pokewalker
>Safari Zone removed
>Game Corner removed
>Lyra meets you in every city and gives you an unnecessary, overpowered item each time
>Rival's personality is completely retconned, now he's friendly and got his pokemon alongside you; picks the one that's weak to yours
>Level curve isn't fixed except for your starters and Pikachu/Eevee, which level up ludicrously fast, bolstered by the already slow level curve
