>>48284879X Speed is great on Defenders because slows are half of the CC in this game. Mobility is valuable on Defenders because it helps you engage and chase targets. It also covers more distance than Eject Button.
Full Heal is great against teams with a lot of stuns, but it's more of a safety net because you can't see what your enemies pick until you enter the game. It's pretty decent on Speedsters though.
Slow Smoke is great on Supporters because it has a very strong slow and can be used both offensively and defensively. But do note that the smoke only lasts 1 second, the slow lasts 2 seconds, and standing in the smoke doesn't refresh the slow. Supporters don't need Eject Button because they're meant to rely on good positioning, and they're usually not the first targets to get focused in a team fight. No one ever expects the support to use Slow Smoke either.
The other hold items are shit because they're either too weak or they need a complete rework.