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I'm gonna go off on a limb and say that the Orange Islands saga is mostly original, but they probably incorporated a few ideas from whatever they planned for Spaceworld 97. Specifically:
>The GS ball was designed for Spaceworld
>Some filler episodes which originally focused on upcoming Pokémon were replaced with original or existing Pokémon (Darumaka doll, Tracey's Venonat, Crystal Onix, Pink Island, Kabuto island, the Ghost Pokémon on the ship, the island of Meowth worshippers, Magnemite, Bulbasaur tentacle monster, Wartortle)
>The 2 year delay of Gold and Silver was probably more disruptive to the anime than the 4-month Porygon delay.