>>38977289The biggest regional Pokédex so far has been Kalos with ~450 (split into three separate listings), followed by USM Alola with ~400, and then SM Alola and BW2 Unova with ~300.
Excluding the new Pokémon revealed so far, there are 809 Pokémon overall. With this in mind, it's probably that AT LEAST half will be cut, but most likely even more than that seeing as the new Pokémon will probably bring the total to almost 900.