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Gen1: Best designs. Shitty gameplay balance. Bad bugs.
Gen2: Second best designs, they still have the somewhat cartoony but semi-realistic animal look. Much better fixes to bugs.
Gen3: Alright designs. Started getting too cartoony. Good graphics and few bugs from here on.
Gen4: Decent designs, better than Gen3 but a change is becoming apparent that they are going for less of an organic feel and more of a cartoony/mechanical feel with their designs.
Gen5: Worst designs so far. Everything has a head three times larger than its body and eyes the size of saucer plates, or has too many tubes/spikes/useless wrist-mounted wings to be taken seriously.
Gen6: Suffers from the same cartoony childish bloated-head syndrome that Gen5 suffered from, but the spiky/pointy/tuby edgy-as-fuck pokemon have been taken down a notch. Second worst designs so far.