>>51556580https://pokeclicker.miraheze.org/wiki/Farming_Setups#Squirtbottle_Leveling_StrategiesDepends on what you have and how much attention you wanna put onto it. Occa+Kasib if you want to let it run mostly by itself and can handle the setup time, Kasib+Sitrus if you are fine with setting it up every 20 minutes, and Pecha+Oran if you want to go fast , though you have to practically stay on the farm the whole time for that last one.
>>51556604Everything can be worth hoarding if you're willing to wait for a good deal. Here are the best ones for the next 30 days for example, assuming you have all slots unlocked. Even if you aren't willing to wait that much, it's good to only cash out the right amount you need for an upgrade, and keep the rest, trading whenever a good deal comes up.
Rule of thumb is that the more valuable an item is, the less probable is to find a deal where you can get something better out of them, so Heart Scales are a good choice to cash out if you need the diamonds. (though yes, there is a good chain in pic related with them in it, so if you can, do save your heart scales and cash out something else instead, like odd keystones)