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Mable (blue hair) should have a gadget orbiting her that shot ice beam like attack that frost your pokemon (contrasting that her main pokemon is Houndoom and always start battling with a fire move), this machine only have 3 shots that are shown their countdown on the machine, the machine fires the ice beam every time you send out a pokemon, making the third shot being blockeable by sending out you first pokemon that was already frozen. This affects pokemon that cant be frozen too.
Xerosic, being some shady basement dweller guy, could have a gadget orbiting over your pokemon, this machine could make a gravity like attack that lowers the speed, attack and special attack by one, this attack is made every time you send out a pokemon. Being the main scientist is going to be the hardest to defeat, so the last 2 grunts you defeat before metting him will break the 4 wall (in their own in-character way) warning you about Xerosic recomending you to save your game before battling him.