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Remaking Gen I actually has some potential. I mean, Kanto itself probably won't change all that much, but... what about the Sevii Islands?
They could do a lot there: make the whole region Surf-able (not that likely), fill it with a region-wide Battle Frontier (each island could have its own facility (in addition to Quest/Seven Island's Battle Tower), or better yet...
... they could give each of the islands their own Gym (plus an eighth one somewhere- maybe on Outcast Island) and its own Elite Four and Champion.