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I did a sapphire nuzlocke once. I built up this entire headcanon where Steven was the bad guy who established the "win or die" rules of the pokemon universe and I had to stop him.
Now, I'm pretty impatient, but after what felt like ages of grinding I got most of pokemon close to lvl 50, and made it all the way to Steven.
He swiped my entire team with his cradily when I allowed it to use Ancientpower too often.
But I didn't give up. I built an entire new team, even catching two regis (yes you can catch them before E4). Note that I didn't catch Kyogre because I allowed it to escape.
I made it all the way to Steven again, only to be defeated by his final pokemon (metagross). I fucking threw my GBA at this point.
I mean, it was pretty intense, for sure, but never again /vp/. Never again.