>>43201760Cerulean Cave, the game's final dungeon, receives the most significant overhaul, sporting a completely different layout. These designs would later be reused for the international Pokémon Red and Blue. Indigo Plateau remains unaltered.
All Pokémon have new front sprites but retain the same back sprites from Red and Green.
Trainers and the literal Ghost have the same sprites from Red and Green. The sprites from Blue would later be used in the international Pokémon Red and Blue.
Pokémon have new Pokédex entries.
In-game trades are changed to different Pokémon.
Game Corner prizes and slot machine icons are different.
The introduction of the game features a battle between a Gengar and a Jigglypuff, as opposed to a Gengar and a Nidorino, as it was in Pokémon Red and Green. This change carried on into the localized version of Pokémon Blue, while the original appeared in the localized Pokémon Red.