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How about instead of a new region, it’s a different era completely? With an amped up difficulty set in medieval times where Pokémon boxes are replaced by farms or something to keep your Pokémon at. Erase Pokémon Centers and rely more on items. Also no generic pokeballs. Just apricorn balls like they did in the old days. To offset limited money, gathering materials to craft healing items or do jobs to earn money. Also, scratch the 8 gym format and have a serious darker plot take place. Oh and you’re not a kid.