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Ash Ketchum eventually grew older, fell in love with Misty, and had a beautiful young daughter who he cherished.
He still went on adventures, still befriended and saved Pokemon, still competed in tournaments. He became a rugged, adventurous man who never lost his childlike wonder.
Unfortunately, while in his mid 50s, doing a promotional video on the conservation of Mantine, the water-type was unexpectedly provoked, striking Ketchum in the chest with it's defensive tail rod, shattering his ribs and infecting him with a fast-acting Neurotoxin
Misty never remarried, Ash left behind two children. He inspired a generation of people to love and protect pokemon, but unfortunately his death lead to an uptick of ignorant kantonians killing wild Mantiine in revenge, something Ash would never have stood for.
It's hard to say if Ash was right or wrong. The Mantine was merely acting on its defensive instincts, is it truly impossible to love and befriend every pokemon? The man who tried the hardest failed and died, but does that mean we should give up?