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Monotype runs are a blast. I've done Grass, Normal, Ghost, Dark, Fire and Water and they were all super fun. Grass was easily the hardest, Normal the easiest, Water was the most fun and Dark was the most boring. Pic related is my current Ice run of X.
But when I do monotype runs, I use "Gym Leader rules", which to me means I can only have 4 Pokemon, unless the 5th shares an evolutionary line with another member of the team. So for example on my Grass run I had a Vileplume and a Belossom,or in my Normal run I had a Slaking and a Vigoroth. The rest of them I only had a team of four.
This is what I do to spice up a playthrough. Probably sounds autistic as fuck to some people though.