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Heatran is known as Hellfrog in the west, but is considered cockroach-themed in Japan.
Heatran's "eyes" are mimicry. They do not change for things such as emotion or sleeping.
Heatran has both male and female versions, but cannot breed at day-care centers.
Heatran's Pokedex entries are extremely mediocre for a Legendary Pokemon. Some interpret this to mean Heatran's status is from human deification. It is extremely powerful in battle regardless.
Heatran has 5 quad resists. This makes it absolutely horrible in Inverse Battles.
Heatran can learn Bug Bite by Move Tutor. This makes it the only one to not be Bug type, in the Bug breeding group, or have a setting of preying on Bug-type Pokemon.
In the anime, a generic character entered the Pokemon League with Heatran. They did not do well.