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They would likely be much uglier; Rita would have a plain, stocky androgynous look with shaved hair and you'll only know she's a girl because of her name and her hair being died pink or light blue. Grusha would be a flamboyant fag but look less feminine than he does. Most of the dialogue they'd have would have them contantly mentioning that they always knew they were different but became much happier and fulfilled when they accepted who they are besides being looked down by bigots.
Rita's tie and Grusha's scarf would be colored after a memegender flag.