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To defeat the Karenfag, one must understand the mindset of the Karenfag.
To this end, you first must begin with the truth that the Karenfags are self-deluded. They are the sort of humans that believe that love and peace will triumph over all. This is of course, ridiculous. Thus, when the Karenfag sends out their favorite Pokemon, it is recommended that the Smogon elite do not merely faint it, but humiliate it, with the goal of showing the Karenfag how weak and pathetic their favorites are. Once this is accomplished, the only way to confirm that the Karenfag is no longer a Karenfag is to personally see to it that they release their inferior Pokemon and begin teaching them about Natures and tier lists.