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Nobody asked for this, but I decided to track the healing/shielding output of Blissey as a function of level to see whether one option was objectively superior over the other. Unfortunately, while Safeguard+ apparently increases the shielding at level 12 I can not find any source on exactly how much that is meant to be. Regardless, it is clear that Safeguard is certainly the superior choice if all you're doing is mashing ZR up until level 12. Afterwards, it's a complete mystery.