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Indiana could be alright
Wild area / safari zone in the far northeast where all the Amish live
Ghost town in the far northwest where Gary is
Caves in the south
Abandoned nuclear powerplant in the southeast could give some fun new type pairings or a legit legendary
Urban core right in the middle could be where the elite 4 is
Ice types year round in the city of Santa Claus
Lots of river routes
Night/day cycle combined with season cycle to keep it interesting
Legendaries aren't gods, just super rare creatures of tall tales. Like the Beast of Busco