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Oh man...so how many times have you guys watched the scene? Hahaha. I stillllllllll can't believe what happened this morning honestly, it's so surreal right now.
I honestly don't think it's the end of Serena for good, you can think that since she kissed Ash, that completes her story, but remember that she isn't going to Johto. Serena is going to be traveling around and at the very least we'll get a cameo.
Also guys, since this just happened and Twitter is exploding...think about it this way. Don't you think that in the future if they hint a Serena return, there would be a huge interest/hype among a lot of people because of what we just witnessed. People are going to tune into that future episode to see what happens with Serena and Amourshipping. So I actually think her kissing Ash gives her more of a chance to return than if she didn't, that's my logic.