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>Kanto Route 4 is a one-way road straight to Cerulean, and with it Mewtwo
>Unova Route 4 goes through the ruins of an ancient civilization, and is next to the place with human ghost Pokemon wearing death masks
>Unova Route 13 is the access point to the Giant Chasm, home of Kyurem which is said to have eaten people and Pokemon
>Kalos Route 13 is an desert, and has a power plant Team Flare hijacked as part of their plan to kill everyone but themselves.
>Hoenn Route 108 has Sea Mauville
>Spiritomb is #108 in the Sinnoh dex, weighs 108kg, and is found in the aforementioned Sea Mauville