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The end of my Black randomized nuzlocke was a real rollercoaster. Lenora led with a Drifloon without Aftermath, but her ace was a fucking Reshiram. It burnt through my entire team, which was only able to inflict chip damage and paralyze it (courtest of Flaaffy, my starter), until she arrived at Dusknoir. I hit it with a Confuse Ray and then spammed Ice Beam, which he learned through a TM in Wellspring Cave. She healed it, but through a combo Dusknoir's bulk and luck with confusion hacks (paralysis somehow never triggered once) I managed to get her down to 1 blip of HP before she finished Dusknoir with Fire Fang.
The worst part is that I had an Espeon with Quick Attack that couldn't participate in the battle because I got it from a fossil, meaning it came in at level 25. Even so, if I hadn't been playing with an item limit, I could've won with Dusknoir with just one more 20 HP potion.