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Hi, I am bar none the hardest mainline game to Nuzlocke.
I dare you to even attempt to prove me wrong. If we're talking about a blind Nuzlocke, then it's even harder. This game was designed to fuck Nuzlockers shit up.
>Double Furfrou battle
>Mr Mime + Machoke battle
>Wobbuffet cave
>Sawk trainer
>Hawlucha trainer
>2nd and 3rd gym can fuck your shit up if you're not careful
>Lysandre. 3 fucking times.
Now admittedly, the game does get a bit easier after the Lysandre battles, and the elite 4 are just a joke, but a lot of things before that point are scary as fuck, even for the well prepared.
I know a lot of people don't like watching LP's, but for those that do, you may notice that most LPers that choose not to use exp share on their X and Y nuzlocke runs tend to FAIL. I can list at least 5 big names that usually breeze through nuzlockes that failed this shit. X and Y is the only mainline game I failed to nuzlocke on my first try too.