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I'm having a blast right now. Doing an all Big Guy run on my X, mostly inspired by pic related. Not going for fully viable natures, just ones that don't necessarily decrease the most important offensive stat. So far I've gotten lucky and only had to re-capture my Rhyhorn. Current team is:
Chesnaught, Naughty, level 41
Blastoise, Calm, level 40
Pangoro, Gentle, level 40
Rhyhorn, Lonely, level 40
Nidoking, Naive, level 40
Last memeber will be either Tyranitar or Aggron. Most likely going for Aggron for Fairy resistances.
Going with a theme gives you the opportunity to try out mons you've never used before. And in my case they're all fairly slow and usually go second in battles, so it's quite different from what I'm used to, but it's really fun.