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Kanto is a small time region, slowly being overrun with large cities and technologies, losing it's history and pride.
Jhoto is a lot like Kanto, only already more modernized and more outgoing. Kanto and Jhoto could be considered the same region.
Hoess is a resort. Everyone is happy, the weather is nice and sunny. Everything is leisurely on the coastside towns. It is exotic and full of mystery.
Sinnoh is rough. Many mountains, almost all men grow up to work in the mines underground. While Sinnoh is making technological advances, it is still very myth-driven, ,ostly poor, and tough.
Unova is rich. It is completely modernized and set up as a perfect region of commerce and communication. Most everyone is happy with their lives and their new technology.