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It's not quite the same as multiple regions, but suppose a game implements some kind of time travel mechanic that lets the player travel to the past and see a different, older version of the region. The player must solve some quest in the past or bring an item from the past to remove some roadblock in the present. Make it so the game is set in Japan and time travel lets to go to Edo era Japan and reddit plankton will cream their pants who I am kidding, I would too