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Gen 1 was all about genes—Mew, Mewtwo, Ditto (literal puddle of genetic material), Eevee, even artificial Pokemon like Porygon (“birthed” by humanity’s technological prowess) all follow the same basic theme
I think Ditto’s shiny being blue was not a coincidence. Scizor and Kabutops both have green shinies, referencing Scyther, for instance, or Electrode being a Great Ball instead of a Pokeball. Most shinies were chosen seemingly at random, but several show that the devs had a plan in mind