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I think whats very fascinating about Misty is also related to Brock. That being their home life and careers.
>Misty's parents never appear in the anime. At most we know that they were attractive looking and were good battlers according to Misty's older sisters.
>Misty's parents are not offscreen working at the gym, they just are never home.
>Brock's parents we know of, Flint and Lola. Both of which we know basically decided to abandon their family to pursue their own careers. Flint being a failure when it came to becoming a stronger trainer. Lola trying to pursue an artistic career.
>Misty, being the youngest sibling, has to deal with her older siblings being rude to her, only were annoyed that she took pokemon, not that she ran away from home, often talk bad about her behind her back.
>Brock, being the eldest sibling, treats his younger siblings with care and love and treats them well. In turn his younger siblings are nice to him.
>Misty became a strong gym leader to spite her sisters. Said sisters who honestly wanted nothing to do with the gym aside from a place to crash and the attention that came with it.
>Brock became a doctor in training, because it was just the natural progression for him who started off as a responsible older brother and also later as a pokemon breeder.
>Misty's feelings for a lot of her screen time were guarded, and she got easily angry and frustrated. Mostly because her sisters created an environment where lashing out was the only way she could feel like she had any modicum of agency.
>Meanwhile Brock doesn't need to lash out as his home life with siblings was far more healthy. Which is also why he is often more level-headed as he had to deal with several siblings wants and needs.