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It would be cool if Unova got its own lake guardian in a new game as Hisui got a genie making a quartet, but the original three are based on the three sacred treasures of Japan.
If they still wanted to do something then they could make Unovas completely separate and make its thing be Freedom.
Possibly Shaymin can be used to explain how Unova went from an annihilated wasteland after Reshiram and Zekrom fought to actually having life.
The starters that make the most sense for a new unova game imo are
>fennekin
Sorry but america literally has small desert foxes and is also the origin of canids, it just makes sense for this.
>sobble
But rather than the boring cowboy everyone says it becomes, instead it's a knight that uses water blades
>turtwig
World turtle myth, Hisui also had a unova mon as a starter so trading makes sense. Not having it be turtwig is a complete waste.