>>44658278SS Elesa is good but doesn't get great until 2/5 and 3/5 with some of her grid stuff. Serena on the other hand can put all the opponents to sleep with one move, and has access to the important hypnosis grid even at 1/5. For just one pull Serena will probably get you more bang for your buck, but it depends a lot on what kind of pair you need.
>>44658282Use him as an evasion tank/debuff spammer. Use something similar to pic related for his grid, and just spam swift. You can also go for a sync nuke build, but other pairs do that better and Mew is bulky enough to make a fantastic tank, especially on top of debuff spam. Get him up to 5* for even more bulk.
>>44658288Red/Serena is already a good combo, but honestly Red doesn't even need it. Get him to 3/5 6* eventually and he actually breaks the game.