>>55499256>south americaImagine exploring rainforests and a not!Inca or Aztec city. Imagine a llama Pokemon aside from Arceus.
>middle eastAdmittedly this one would be best as a single-city game, but it turns out having a ton of oil means that some places are incredibly opulent (while surrounded by immense poverty).
>AfricaHas some nice places, especially port towns. Not sure if there's enough for an entire game, but it's no longer all mud huts and naked savages like 200 years ago. A good opportunity for regional or just normal versions of Zebstrika, Pyroar, Hippowdon, etc. We could even get a cheetah.
>South AsiaAdmittedly I don't know much about this region, but I'm sure you could pull something out of it.
Besides, it's not like Unova has a homeless/migrant/drug/race problem on full display, and Kalos doesn't have a 20% daily chance to shut down because of strikes. Regions are all more idyllic versions of what they're based on.