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PSMD Mewtwo can suck my dick. Just ban Recover and he goes down like a bitch. There are tons of other ways to cheese this fight, too.
You want some tough shit? Rumble Mewtwo EX.
>He shows up at the end of a fucking gauntlet. Said gauntlet is filled with powerful Pokemon with long-ranged attacks which will wombo combo you for over 1/2 your health. The camera does not cooperate with you, it's easy to get blindsided and just fucking destroyed on your way to Mewtwo.
>There's a timer on both the gauntlet and the battle with Mewtwo. This basically forces you to use a Pokemon with EQ so you can get to Mewtwo on-time. But, EQ is so slow that it's impossible to kill him in-time with EQ. So, you have to commit sudoku, leaving you with 2 Pokemon AT MOST to deal with Mewtwo.
>Unlike any Pokemon in the game, Mewtwo is completely immune to hitstun. This means you can't stunlock him, and you're constantly running in and out of his range just to land a hit. This runs the timer down even more.
>Mewtwo's attacks create huge hitboxes all around him, and combo into themselves dealing huge damage and probably killing you in one combo.
There are very few Pokemon that can even deal enough damage to take out Mewtwo on-time, and due to the way that the game works, you probably don't have them when you first reach Mewtwo. Getting high-powered Pokemon and good moves is all up to luck in Pokemon Rumble, and there's no way to level up, either. The only way to learn moves is also completely random and costs a fucking fortune.
I've never had to look up "how do I beat x?" in any Pokemon game other than this one. There's no Pokemon battle harder than Rumble Mewtwo EX.