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Am I the only one who thinks maybe she DOES know about Mohn, and maybe went extra crazy upon realizing his amnesia or whatever? Too many NPCs treat him like common knowledge not to. I think it because he wouldn't be the first family member she just gave up on after feeling "abandoned" by him. She absolutely could have made Guzma hand over Gladion had she really wanted him back.
I feel like it's more
>Mohn disappears
>Lusamine slowly starts losing it and this is when she begins getting obsessed with UBs
>Mohn reappears on Pelago
>When Lusamine finds him and tries to bring him back, he doesnt, whether it's amnesia or just is done with Ultra Beasts forever
>Lusamine, already unstable, sees it as a personal attack against her, snaps, and pretends he's dead to her
>probably goes back and tells her kids their father is dead
>from now on whenever someone leaves her, instead of chasing after them, she just lets them rot on their own