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Honestly, I think every region had its strengths and weaknesses. Kanto is the only one I probably wouldn't revisit unless I was replaying HG/SS since it's such a dated, barebones region.
If I had to rank them based on design, comfiness, diversity and how memorable they were, it would be something like Johto > Unova > Hoenn > Kalos > Sinnoh > Kanto.